Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3010 | 3010-30305 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, V75T, T215Y | D67G, M184T, K219Q, N348I | K20R, T39A, S68G, A98S, V118VI, D123E, I135T, I178M, T200TA, F214FL, D218E, I293V, A327V, I341F, A376S, T377M, T386I | L210LIST, T240M |
| >3010-30305| codons 2-399 ISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPVF AIKKKGGTRWRKITDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPLD KEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVIY QYTDDLYVGSDLEIGQHRAKIEELRQHLTRWGLYTPEQKHQKEPPFLWMGYELHPDKWMV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAEL ELAENREILKEPVHGVYYDPSKDLIVEIQKQGQGQWTYQFYQEPFKILKTGKYARMRGAH TNDVKQLTEAVQKISMESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33F, F53L, Q58E, G73S | L10I, I13V, I15V, K20R, E35D, M36I, R41K, K55H, R57K, I62V, L63P, A71V, I72R |
| >3010-30305| codons 1-99 PQITLWQRPIVTVKVGGQLREALLDTGADDTVFEDINLPGKWKPKLIGGIGGLVHVKEYD QVPIEICGHKVRSTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |