<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3010 3010-30305 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L74I, V75T, T215Y D67G, M184T, K219Q, N348I     K20R, T39A, S68G, A98S, V118VI, D123E, I135T, I178M, T200TA, F214FL, D218E, I293V, A327V, I341F, A376S, T377M, T386I L210LIST, T240M
>3010-30305| codons 2-399
ISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPVF
AIKKKGGTRWRKITDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPLD
KEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVIY
QYTDDLYVGSDLEIGQHRAKIEELRQHLTRWGLYTPEQKHQKEPPFLWMGYELHPDKWMV
QPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAEL
ELAENREILKEPVHGVYYDPSKDLIVEIQKQGQGQWTYQFYQEPFKILKTGKYARMRGAH
TNDVKQLTEAVQKISMESIVIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L33F, F53L, Q58E, G73S L10I, I13V, I15V, K20R, E35D, M36I, R41K, K55H, R57K, I62V, L63P, A71V, I72R  
>3010-30305| codons 1-99
PQITLWQRPIVTVKVGGQLREALLDTGADDTVFEDINLPGKWKPKLIGGIGGLVHVKEYD
QVPIEICGHKVRSTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006