<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3010 3010-30305 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L74I, T215Y D67G, V75T, M184T, K219Q, N348I     P1L, K20R, T39A, S68G, A98S, V118VI, D123E, I135T, I178M, T200TA, F214FL, D218E, I293V, A327V, I341F, A376S, T377M, T386I, A400T L210LIST, T240M
>3010-30305| codons 1-400
LISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKGGTRWRKITDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI
YQYTDDLYVGSDLEIGQHRAKIEELRQHLTRWGLYTPEQKHQKEPPFLWMGYELHPDKWM
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIVEIQKQGQGQWTYQFYQEPFKILKTGKYARMRGA
HTNDVKQLTEAVQKISMESIVIWGKIPKFKLPIQKETWET

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L33F, F53L, Q58E, G73S L10I, I13V, I15V, K20R, E35D, M36I, R41K, K55H, R57K, I62V, L63P, A71V, I72R  
>3010-30305| codons 1-99
PQITLWQRPIVTVKVGGQLREALLDTGADDTVFEDINLPGKWKPKLIGGIGGLVHVKEYD
QVPIEICGHKVRSTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006