Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3009 | 3009-30303 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, V82VA, I84IV | L33F | L10IV, I13IV, G16E, L19LI, K20R, E35D, M36I, N37D, R57K, I62V, L63APT, I64V, A71V, I93L |
| >3009-30303| codons 1-99 PQITLWQRPVVTVKIEGQIREALLDTGADDTVFEDIDLPGRWKPKIIGGIGGFMKVKQYD QVTVEICGHKVIGTVVVGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215F | V35I, D123E, I135T, I178IM, T200E, V245Q, A272P, K277R, I293V, E297K, Q334H, M357T, G359GS, T362TS, K366KR, T369V, S379G, T386V, K390R |
| >3009-30303| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHREKIEELRQHLLRWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYARTRSA HSNDVRQLVEAVQKIATEGIVIWGKVPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |