Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3008 | 3008-30227 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, M184V, L210W, T215Y | K219N, N348I | Y188L | K22R, V35T, K43KE, E44EA, V106I, V118I, K122P, I135T, V179VI, V189VI, T200R, L205F, H208Y, R211K, K223Q, V245K, D250E, A272P, T286A, I293V, K311R, G335GD, M357T, K390R, Q394L |
| >3008-30227| codons 1-399 PISPIETVPVKLKPGMDGPKVRQWPLTEEKIKALTEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLLIGSDLEIGQHRRKIEEFRQYLWKWGFYTPDNKHQQEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKILKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPILKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | L33F, K43T, F53L, G73C | L10V, I13V, G16A, K20R, M36I, L63P, A71V |
| >3008-30227| codons 1-99 PQITLWQRPVVTVKIAGQLREALLDTGADDTIFEEINLPGRWTPKIVGGIGGLMKVRQYD QIPIEICGHKVICTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |