<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3007 3007-30303 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, I84V L24I L10I, T12P, I15V, L19P, K20R, M36I, I62V, L63P, A71T, I85V  
>3007-30303| codons 1-99
PQITLWQRPIVPIKVGGQPREALIDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD
QVPIEICGHKTIGTVLVGPTPTNVVGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75M G190A K101H V35L, K43Q, E44D, K82R, V118I, K122E, D123E, A158S, G196E, R211K, D237E, V245M, A272P, K275R, Q278QH, K281KR, L283LI, I293V, P294T, R358K, G359S, A371V I63IM
>3007-30303| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEQDGKISKIGPENPYNTPV
FAMKKKNSTKWRKLMDFRELNRRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPEKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKHLCRLIRGTKALTEVVTLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006