Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3007 | 3007-30303 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V | L24I | L10I, T12P, I15V, L19P, K20R, M36I, I62V, L63P, A71T, I85V |
| >3007-30303| codons 1-99 PQITLWQRPIVPIKVGGQPREALIDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKTIGTVLVGPTPTNVVGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | G190A | K101H | V35L, K43Q, E44D, K82R, V118I, K122E, D123E, A158S, G196E, R211K, D237E, V245M, A272P, K275R, Q278QH, K281KR, L283LI, I293V, P294T, R358K, G359S, A371V | I63IM |
| >3007-30303| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEQDGKISKIGPENPYNTPV FAMKKKNSTKWRKLMDFRELNRRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPEKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKHLCRLIRGTKALTEVVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |