Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3006 | 3006-30226 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, M184V, L210W, T215Y | K103N | V108I | T39A, E44D, V60VI, K82R, R83K, V90VI, V118I, K122E, I135T, T200E, E203K, Q207E, H208HY, R211K, E224ED, A272P, V276T, K277R, K311R, Q334N, G335D, R356K, G359S, S379C, K385KN, A400AT | K223KPQT |
| >3006-30226| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI FAIKKKNSDKWRKIVDFRELNRKTQDFWEIQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHREKIKELREYLWKWGFYTPDKKHQTDPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCKLLRGTKALTEVIPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIATECIVIWGNTPKFKLPIQKETWET |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54S, V82A, I84V | L33F | L10I, R41K, D60E, I62V, L63P, A71L, V77I, I93L | T91TAGS |
| >3006-30226| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGKWKPKLIVGIGGFSKVRQYE QVPIEICGHKLIGTVLIGPTPANVIGRNLLSQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |