Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3005 | 3005-30226 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, M184V, T215F | V75S, K219W | K101E, Y181C, G190A | V108I | K43N, V118I, K122E, D123E, I135T, V179I, V189I, Q207E, L210S, F214L, K223Q, L228H, V245M, A272P, I293V, E297A, Q334QL, G335S, R358K, G359S, A371V, I375V, A376T, T386I, K390R |
| >3005-30226| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKNSDKWRKISDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYIASDLEIGQHRTKIEELREHLSRWGLFTPDWKHQQEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLSQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEVVQKVTTESIVIWGKIPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, L33I, G73S | A22V, E35D, M36I, I62V, L63P, A71V, I72L, N83S, I85V |
| >3005-30226| codons 1-99 PQITLWQRPFITIKIGGQLKEVLLDTGADDTVIEDINLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVLSTVLVGPTPVSVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |