<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3005 3005-30226 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, V11I, L33I, G73S A22V, E35D, M36I, I62V, L63P, A71V, I72L, N83S, I85V  
>3005-30226| codons 1-99
PQITLWQRPFITIKIGGQLKEVLLDTGADDTVIEDINLPGRWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVLSTVLVGPTPVSVVGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74I, M184V, T215F V75S, K219W K101E, Y181C, G190A V108I K43N, V118I, K122E, D123E, I135T, V179I, V189I, Q207E, L210S, F214L, K223Q, L228H, V245M, A272P, I293V, E297A, Q334QL, G335S, R358K, G359S, A371V, I375V, A376T, T386I, K390R  
>3005-30226| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKNSDKWRKISDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
CQYVDDLYIASDLEIGQHRTKIEELREHLSRWGLFTPDWKHQQEPPFHWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLSQWTYQIYQEPFKNLKTGKYARMKSA
HTNDVKQLTEVVQKVTTESIVIWGKIPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006