Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3004 | 3004-30226 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | K219Q | G190A | K20R, V35L, T69N, K122E, D123E, I135T, S162N, D177E, G196E, F214L, K223Q, L228H, D237E, Q242H, V245I, L283I, A288T, V292VI, I293V, E297K, Q334D, K347KR, A360T, A371V, A376S, T386TI, K388R, K390R |
| >3004-30226| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPEIVI YQYVDDLYVASDLEIEQHRTKIEELRQHLLRWGLFTPDQKHQQEPPFHWMGYELHPEKWT VHPIILPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKTLTEIVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQIYQEPFRNLKTGKYARMRGT HTNDVKQLTEVVQKISTESIVIWGKIPRFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V | L10F, L24I, G73S | I15V, K20V, M36I, L63P, A71V, I85V |
| >3004-30226| codons 1-99 PQITLWQRPFVTIKVGGQLVEALIDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKVISTVLVGPTPTNVVGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |