<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3004 3004-30226 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, I84V L10F, L24I, G73S I15V, K20V, M36I, L63P, A71V, I85V  
>3004-30226| codons 1-99
PQITLWQRPFVTIKVGGQLVEALIDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD
QIPIEICGHKVISTVLVGPTPTNVVGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, T215F K219Q G190A   K20R, V35L, T69N, K122E, D123E, I135T, S162N, D177E, G196E, F214L, K223Q, L228H, D237E, Q242H, V245I, L283I, A288T, V292VI, I293V, E297K, Q334D, K347KR, A360T, A371V, A376S, T386TI, K388R, K390R  
>3004-30226| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPEIVI
YQYVDDLYVASDLEIEQHRTKIEELRQHLLRWGLFTPDQKHQQEPPFHWMGYELHPEKWT
VHPIILPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKTLTEIVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQIYQEPFRNLKTGKYARMRGT
HTNDVKQLTEVVQKISTESIVIWGKIPRFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006