<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3003 3003-30225 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219N L100I, K103N   K43E, E44A, W88C, V118I, D121H, K122E, I142V, D177E, V179I, Q197R, T200E, E203K, Q207E, H208Y, R211K, V245E, S251H, K277R, T286A, A288T, I293V, E297K, R356K, M357I, G359S, V365I, K390R  
>3003-30225| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFCEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
HEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII
YQYVDDLYVGSDLEIGRHREKIKELREYLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDHWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKTLTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKIRSA
HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I54V, V82A, I84V L23I, L24LI, F53FL L10I, I15V, G16GE, L19V, K20M, E35D, M36I, R41RK, K45N, K55KR, Q61QH, I62V, L63T, I64V, E65D, I72V, I85IV, T91S  
>3003-30225| codons 1-99
PQITLWQRPIVTIKVEGQVMEAIIDTGADDTVLEDINLPGKWKPNIIGGIGGLVRVRQYD
HVTVDICGHKAVGTVLVGPTPANVVGRNLLSQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006