Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3003 | 3003-30225 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | L100I, K103N | K43E, E44A, W88C, V118I, D121H, K122E, I142V, D177E, V179I, Q197R, T200E, E203K, Q207E, H208Y, R211K, V245E, S251H, K277R, T286A, A288T, I293V, E297K, R356K, M357I, G359S, V365I, K390R |
| >3003-30225| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFCEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII YQYVDDLYVGSDLEIGRHREKIKELREYLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIELPEKDHWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKTLTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKIRSA HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82A, I84V | L23I, L24LI, F53FL | L10I, I15V, G16GE, L19V, K20M, E35D, M36I, R41RK, K45N, K55KR, Q61QH, I62V, L63T, I64V, E65D, I72V, I85IV, T91S |
| >3003-30225| codons 1-99 PQITLWQRPIVTIKVEGQVMEAIIDTGADDTVLEDINLPGKWKPNIIGGIGGLVRVRQYD HVTVDICGHKAVGTVLVGPTPANVVGRNLLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |