<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3002 3002-30225 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46L, I47IV, I54M, L90M L33LF, L89V I13V, K20KQ, M36MI, R41K, L63P, A71V  
>3002-30225| codons 1-99
PQITLWQRPLVTVKIGGQLQEALLDTGADDTIFEEINLPGKWKPKLVGGIGGFMKVRQYD
QIPIEICGHKVIGTVLVGPTPVNIIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, D67N, K70R, L74IV, Y115YF, M184V, T215F K219Q Y188L   V60I, T69N, D123E, I135T, T139I, K166R, D177E, V179I, T200A, F214L, D218E, A272P, K277R, E297K, Q334L, N348T, R356K, A360V, V365VI, A376T, E399D  
>3002-30225| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL
DKEFRKYTAFTIPSTNNEIPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIII
YQYVDDLLVGSDLEIGQHRAKIEELRQHLLRWGLFTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKTLKTGKYAKMRGV
HTNDIKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006