<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2622 2622-30908 Switzerland 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y   K101E, Y181C, G190A A98G, V108VI P4S, E44D, V118I, K122E, I135T, S162SC, E169D, Q174QR, V189VI, E203EK, Q207E, H208HY, R211K, D237E, A272P, K277R, T286A, I293IV, K311R, D324E, Q334L, E370D, T386TI, K390R  
>2622-30908| codons 1-399
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKRNPDIVI
CQYVDDLYIASDLEIGQHRTKIKELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPEKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTEEAE
LELAENREILREPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTDAVQKIATESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, V82A, L90M V11I, L33F, G73S, L89V L10V, I13V, L24F, N37D, K45R, L63P, A71I, V77I, I93L  
>2622-30908| codons 1-99
PQITLWQRPVITVKIGGQLKEALFDTGADDTIFEEMDLPGRWKPRIVGGIGGFMKVRQYD
QIPIEICGHKIISTVLIGPTPANIIGRNVMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006