Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2622 | 2622-30908 | Switzerland | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | V11I, L33F, G73S, L89V | L10V, I13V, L24F, N37D, K45R, L63P, A71I, V77I, I93L |
| >2622-30908| codons 1-99 PQITLWQRPVITVKIGGQLKEALFDTGADDTIFEEMDLPGRWKPRIVGGIGGFMKVRQYD QIPIEICGHKIISTVLIGPTPANIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K101E, Y181C, G190A | A98G, V108VI | P4S, E44D, V118I, K122E, I135T, S162SC, E169D, Q174QR, V189VI, E203EK, Q207E, H208HY, R211K, D237E, A272P, K277R, T286A, I293IV, K311R, D324E, Q334L, E370D, T386TI, K390R |
| >2622-30908| codons 1-399 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKRNPDIVI CQYVDDLYIASDLEIGQHRTKIKELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTEEAE LELAENREILREPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTDAVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |