<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2621 2621-30820 Switzerland 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M N88D I13A, K14R, K20I, M36I, R41K, K45R, L63P, I66L, C67Y, H69K, A71I, L89T, T91S  
>2621-30820| codons 1-99
PQITLWQRPLVTARIGGQLIEALLDTGADDTVLEEINLPGKWKPRIIGGIGGFVKVRQYD
QIPIELYGKKIIGTVLVGPTPVNVIGRDTMSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, M184V, T215F   K101PQ, K103NS Y318F V35T, V60I, K122P, I135V, Q174H, D177E, I178M, T200A, Q207E, H208Y, R211K, P243T, V245Q, E248D, D250E, A272P, R284K, T286A, E291D, V292I, I293V, E297A, A304AE, G335D, R356K, M357R, G359S, T369A, A371V, I375V, A376T, T386A, K390R, K395KR, A400T  
>2621-30820| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKSKSVTVLDVGDAYFSVPL
DPDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPEMVI
YQYVDDLYVGSDLEIGQHRAKIEELREYLLKWGFFTPDKKHQKEPPFLWMGYELHPDKWT
VQTIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTDIVPLTAEAE
LELEENREILKEPVHGVFYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRSA
HTNDVKQLAEVVQKVTTESIVIWGKAPKFRLPIQRETWET

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006