Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2620 | 2620-30709 | Switzerland | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70KR, Q151M, M184V | A62V, V75I, F77L, F116Y, T215V, K219E | K103N | V108I | V35T, E40A, K49R, T69N, K102KR, V118I, K122E, D123N, I135M, S162D, E169R, K173E, V189VI, I202V, F214L, F227Y, A272P, K277R, Q278H, E297K, G333DE, Q334CY, R356K, A376T, S379C, K390R | N137S |
| >2620-30709| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTAMEKEGKISRIGPENPYNTPV FVIKKKNSNRWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKRNKSVTILDVGDAYYSIPL DENFRKYTAFTIPSMNSETPGIRYQYNVLPMGWKGSPAIFQDSMTKILRPFREQNPDIVI YQYVDDLYIGSDLEIGQHRTKVEELRQHLLRWGLVTPDEKHQKEPPYLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEYGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKITTECIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50V, V82A, L90M | V11I, L33F, F53L, L89LFV | L10I, I13V, K20R, E34A, E35D, M36I, K55N, R57K, D60E, I62V, L63P, A71V |
| >2620-30709| codons 1-99 PQITLWQRPIITVKIGGQLREALLDTGADDTVFADINLPGRWKPKMIGGVGGLINVKQYE QVPIEICGHKVIGTVLVGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |