<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2620 2620-30709 Switzerland 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70KR, Q151M, M184V A62V, V75I, F77L, F116Y, T215V, K219E K103N V108I V35T, E40A, K49R, T69N, K102KR, V118I, K122E, D123N, I135M, S162D, E169R, K173E, V189VI, I202V, F214L, F227Y, A272P, K277R, Q278H, E297K, G333DE, Q334CY, R356K, A376T, S379C, K390R N137S
>2620-30709| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTAMEKEGKISRIGPENPYNTPV
FVIKKKNSNRWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKRNKSVTILDVGDAYYSIPL
DENFRKYTAFTIPSMNSETPGIRYQYNVLPMGWKGSPAIFQDSMTKILRPFREQNPDIVI
YQYVDDLYIGSDLEIGQHRTKVEELRQHLLRWGLVTPDEKHQKEPPYLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEYGQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVKQLTEAVQKITTECIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I50V, V82A, L90M V11I, L33F, F53L, L89LFV L10I, I13V, K20R, E34A, E35D, M36I, K55N, R57K, D60E, I62V, L63P, A71V  
>2620-30709| codons 1-99
PQITLWQRPIITVKIGGQLREALLDTGADDTVFADINLPGRWKPKMIGGVGGLINVKQYE
QVPIEICGHKVIGTVLVGPTPANIIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006