<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2617 2617-30630 Switzerland 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, I84V, L90M L23I, K43T L10I, T12E, L19V, K20R, E35D, M36IV, I62V, L63P, H69Q, A71I, Q92K, I93M  
>2617-30630| codons 1-99
PQITLWQRPIVEIKIGGQVREAILDTGADDTVLEDVNLPGRWTPKMIGGIGGFVKVRQYD
QVPIEICGQKIIGTVLVGPTPANVIGRNLMTKMGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y N348I     K20R, V35I, T39A, K43E, E44A, V118I, D123E, I135T, I178M, V179I, E194ED, G196E, Q197K, R211K, A272P, E297R, A355T, R356RK, K366R, A376T, K390R F214M
>2617-30630| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEEAGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII
YQYVDDLYVGSDLDIEKHRTKIEELRQHLWKWGMYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYTKMRGA
HTNDVRQLTEAVQKITTESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006