Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2617 | 2617-30630 | Switzerland | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V, L90M | L23I, K43T | L10I, T12E, L19V, K20R, E35D, M36IV, I62V, L63P, H69Q, A71I, Q92K, I93M |
| >2617-30630| codons 1-99 PQITLWQRPIVEIKIGGQVREAILDTGADDTVLEDVNLPGRWTPKMIGGIGGFVKVRQYD QVPIEICGQKIIGTVLVGPTPANVIGRNLMTKMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | N348I | K20R, V35I, T39A, K43E, E44A, V118I, D123E, I135T, I178M, V179I, E194ED, G196E, Q197K, R211K, F214M, A272P, E297R, A355T, R356RK, K366R, A376T, K390R |
| >2617-30630| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEEAGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYVDDLYVGSDLDIEKHRTKIEELRQHLWKWGMYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYTKMRGA HTNDVRQLTEAVQKITTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |