Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2616 | 2616-30806 | Switzerland | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, V75T, M184V, T215F | K219Q | L100I, K103N | K20R, T69N, K102R, D121H, K122E, I135T, S162Y, D177E, V179IT, G196E, I202V, K223T, L228H, A272P, A288T, I293V, G359S |
| >2616-30806| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKITDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEITI YQYVDDLYVGSDLEIEQHRTKVEELRQHLLRWGFFTPDQKHQTEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKTLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54S, V82A, L90M | L33F | L10IV, I13V, E34Q, I62V, L63P, I64L, I66IV, H69R, A71L, I72V, V77I, I93M |
| >2616-30806| codons 1-99 PQITLWQRPVVTVKIGGQLKEALLDTGADDTVFQEMNLPGRWKPKMIVGVGGFSKVRQYD QVPLEVCGRKLVGTVLIGPTPANIIGRNLMTQMGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |