Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2615 | 2615-30708 | Switzerland | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L10F, L24I, L33F | R41K, K55R, R57K, L63P, H69Q, A71V, I93L |
| >2615-30708| codons 1-99 PQITLWQRPFVTIKIGGQLKEALIDTGADDTVFEEMNLPGKWKPKIIGGIGGFVRVKQYD QIPIEICGQKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, D67N, V75T | A62V, K219E | Y181C | K20R, S68N, W88C, T165I, T200A, R211K, F214L, H221Y, A272P, T286TA, A288S, I293IV, E297K, Q334P, G359S, Q373N, A376T, T386A |
| >2615-30708| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKRKNNTKWRKLTDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGLTTPDEKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKSLTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGPGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVNKITTESIVIWGKAPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |