Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2614 | 2614-30624 | Switzerland | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L33F, F53L | L10V, T12I, I15V, G16E, L19V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, I85V, L89M |
| >2614-30624| codons 1-99 PQITLWQRPVVIIKVEGQVREALLDTGADDTVFEDINLPGKWKPKLIGGIGGLVKVKQYD QITIDICGHKATGTVLVGPTPANIVGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | V108VI | K20R, V35T, T39A, V60I, L109LI, D121HY, K122E, I135V, S162H, E169K, K173D, Q174K, D177E, T200A, Q207E, L228H, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, E297A, R356K, G359T, T377L, E399D | D123*G |
| >2614-30624| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTIIDVGDAYFSVPL YEGFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQHSMTKILKPFRDKNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIALESIVIWGKTPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |