<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2614 2614-30624 Switzerland 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L33F, F53L L10V, T12I, I15V, G16E, L19V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, I85V, L89M  
>2614-30624| codons 1-99
PQITLWQRPVVIIKVEGQVREALLDTGADDTVFEDINLPGKWKPKLIGGIGGLVKVKQYD
QITIDICGHKATGTVLVGPTPANIVGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y     V108VI K20R, V35T, T39A, V60I, L109LI, D121HY, K122E, I135V, S162H, E169K, K173D, Q174K, D177E, T200A, Q207E, L228H, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, E297A, R356K, G359T, T377L, E399D D123*G
>2614-30624| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTIIDVGDAYFSVPL
YEGFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQHSMTKILKPFRDKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVQKIALESIVIWGKTPKFKLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006