<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2607 2607-30505 Switzerland 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, M184V, T215Y A62V K103N   V35VI, K43KN, V90I, K122E, D123DN, I135T, S162A, D177DN, L210F, R211K, L283I, T286A, V292VI, I293V, V317A, I326M, G359S, A371V, K390R  
>2607-30505| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENEGKISKIGPENPYNTPV
FVIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPNIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLFKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGAKALTEIVPLTEEAE
LELAENREILKEPVHGAYYDPSKDLMAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54M, L90M L33F, G73T, L89V L10V, I13IV, N37H, R57K, D60E, L63P, A71V, I72E, V77I, V82I, I93L  
>2607-30505| codons 1-99
PQITLWQRPVVTVKIGGQLKEALLDTGADDTVFEEMHLPGRWKPKMIGGIGGFMKVKQYE
QIPIEICGHKVETTVLIGPTPINIIGRNVMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006