Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2606 | 2606-30623 | Switzerland | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | G190A | K20R, V118I, I135T, I178M, V179VI, I195L, G196E, R211K, A272P, E297K, S322A, Q334E, R358K, G359S, A371V, A376S, T386I, E399D |
| >2606-30623| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYVDDLYVASDLELEQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPAKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEVVQKISTESIVIWGKIPKFKLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47A, L90M | L10I, R41K, I62V, L63P, I64V, I85V, I93L |
| >2606-30623| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTILEEMNLPGKWKPKIAGGIGGFIKVRQYD QVPVEICGHKAIGTVLVGPTPVNIVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |