Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2605 | 2605-30317 | Switzerland | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219E | L100I, K103N | K20R, V90I, D123E, I135T, S162Y, K166R, Q207E, R211K, L228H, A272P, E297K, P321S, D324E, Q334N, G359S, T386I |
| >2605-30317| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFFTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDSSKELIAEIQKQGNGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I50V, I54T, V82A | L33I | L10IV, K20R, M36I, N37S, I62V, L63P, I64V, H69R, A71V, I85V |
| >2605-30317| codons 1-99 PQITLWQRPVVTIKIGGQLREALLDTGADDTVIEEISLPGRWKPKLIVGVGGFTKVRQYD QVPVEICGRKVIGTVLVGPTPANIVGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |