Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2603 | 2603-30619 | Switzerland | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K101E, G190A | A98G | K43E, Q174K, D177E, V189I, H208Y, R211K, E248D, A272P, K277R, E291D, V292I, E297A, K311R, G333E, Q334H, R356K, R358K, G359S, K390R |
| >2603-30619| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPEIVI YQYMDDLYIASDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIIPLTAEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKMKSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I84V | L10F | L19I, E35D, M36I, I64V, I72V |
| >2603-30619| codons 1-99 PQITLWQRPFVTIKIGGQIKEALLDTGADDTVLEDINLPGRWKPKLIGGIGGFIKVRQYD QILVEICGHKAVGTVLVGPTPVNVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |