Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2602 | 2602-30415 | Switzerland | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | L10F, L33F | I13V, R41K, Q61H, I62V, L63A, H69Q, A71V, V77I, I93L |
| >2602-30415| codons 1-99 PQITLWQRPFVTVKIGGQLKEALLDTGADDTVFEEMNLPGKWKPKIIGGIGGFVKVRQYD HVAIEICGQKVIGTVVIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | K103NS | E6EK, E44D, R83K, V118I, K173R, Q174K, D177E, Q197L, T200E, E203K, Q207E, K223E, V245K, E248D, A272P, K275R, I293V, E312A, G333E, Q334H, G359S, T369TA, A376V, T386A |
| >2602-30415| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPEIVI YQYVDDLYVGSDLEIGLHREKIKELREHLLRWGFYTPDKKHQEEPPFLWMGYELHPDKWT VQPIKLPDKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKAPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLAEAVQKIVTESIVIWGKAPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |