Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2412 | 2412-30703 | Sweden | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | N348I | K103N | F227L | T39A, V60I, K82KR, D121Y, K122E, I135L, I142M, G196E, E203K, R211N, K223E, L228R, V245T, K277R, A288S, E297K, I329L, V365I, T377R | D113DA |
| >2412-30703| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNRRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGAAYFSVPL YEDFRKYTAFTIPSLNNETPGMRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIKELRQHLWNWGFYTPDKKHQEEPPLRWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKSLTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKILKTGKYARMRGA HTNDIKQLTEAVQKIARESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V, L90M | Q58QE | L10I, I13IV, K20KT, L63P, I64IV, A71V, I72T, T91TS |
| >2412-30703| codons 1-99 PQITLWQRPIVTVKIGGQLTEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD QIPVEICGHKVTGTVLVGPTPTNVIGRNLMSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |