Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2405 | 2405-30826 | Sweden | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A | L10F, K43T, T74P | T12S, I15V, L19T, K20R, M36I, Q61E, I62V, L63P, H69K, L89M, I93L |
| >2405-30826| codons 1-99 PQITLWQRPFVSIKVGGQTREALLDTGADDTVLEEINLPGRWTPKIIGGIGGFIKVRQYD EVPIEICGKKAIGPVLVGPTPANIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, M184V, L210W, T215Y | K103N, Y181YC | A98G, V108I, Y318YF | K20KR, V35T, E36A, T39D, S48E, I135T, K173A, Q174K, D177E, I195L, G196T, T200A, Q207E, R211K, L228H, V245Q, E291D, I293V, P294Q, Q334H, G335D, K350KR, G359T, T377M, T386IV, K390R |
| >2405-30826| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTAICDELEKEGKIEKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI CQYVDDLYVGSDLELTQHRAKIEELREHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDVVQLTEEAE LELAENREILKEPVHGVFYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLRTGKYARMRTA HTNDVKQLTEAVQKIAMESIVIWGKVPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |