Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2401 | 2401-30807 | Sweden | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74V, T215F | K219Q | L100I, K103N, Y181C | P4S, V35VIM, T69N, K122E, D123E, I135L, I202V, R211A, D218E, A272P, K277R, E297A, S322T, I329L, Q334D, F346Y, M357T, A376S, T377L |
| >2401-30807| codons 1-399 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKVEELRQHLLAWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPTKDLIAELQKQGDGQWTYQIYQEPYKNLKTGKYARTRGA HTNDVKQLTEAVQKISLESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10V, K20R, E35D, M36I, N37D, R57RK, L63P, A71V, Q92QK, I93L |
| >2401-30807| codons 1-99 PQITLWQRPVVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVKQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTKLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |