Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2254 | 2254-30930 | Portugal | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S, L90M | L33F, Q58E | L10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TS |
| >2254-30930| codons 1-99 PQITLWQRPVVTVKVGGQIREALLDTGADDTVFEDIDLPGKWKPKMIVGIGGFVRVKEYD QVPIEICGKKTIGSVLVGPTPSNIVGRNIMTQLGFSLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219W | K101E, Y181C | A98G, V108I | V8VI, K20R, E28K, K32E, V35K, T39E, V118I, K122E, D123S, I135T, E138A, K173A, D177G, V179I, T200A, E203K, L205F, Q207D, H208Y, L210S, R211K, D218E, K223Q, L228H, Q242K, V245Q, K275Q, T286A, E291D, V292I, I293V, Q334E, G335D, R356K, M357R, G359T, T377L, K385R, K390R |
| >2254-30930| codons 1-399 PISPIETIPVKLKPGMDGPRVKQWPLTKEKIEALKEICEEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTILDVGDAYFSIPL DESFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPGIII CQYVDDLYVGSDLEIGQHRAKIKEFRDYLSKWGFFTPEWKHQQEPPFHWMGYELHPDKWT VKPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIQVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEDQWTYQIYQEPFKNLKTGKYAKRRTA HTNDVKQLTEAVQKIALESIVIWGRTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |