<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2251 2251-30925 Portugal 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48M, I54V, V82A L24I, F53L, G73GCFV L10I, T12I, I15V, G17E, K20M, E35D, M36I, K43R, R57K, Q61N, I62IV, L63P, T91TS  
>2251-30925| codons 1-99
PQITLWQRPIVIIKVGEQLMEALIDTGADDTVLEDINLPGRWRPKMIMGIGGLVKVKQYD
NVPIEICGHKAIVTVLVGPTPANIIGRNLLSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, M184V, L210W, T215Y K219R Y181C V108I, K238N T7TA, K20R, V35VAIT, K43E, E44D, V60I, K101Q, V118I, K122E, I135L, S162Y, K173A, Q174K, I178L, G196E, Q197L, E203K, Q207E, R211A, K223Q, L228H, D237E, V241M, V245Q, E248D, A272P, V276VAIT, L283I, T286A, E291D, V292VI, I293V, E297HQ, V314VA, V317A, R356K, G359S, A371T, T377LQ, S379C, K390R, E399D  
>2251-30925| codons 1-399
PISPIEAVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEEDGKISKIGPENPYNTPI
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRAKNPDLVI
CQYVDDLYVGSDLEIELHRTKIKELREHLWAWGFYTPDRKHQQEPPFHWMGYELHPENWT
MQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKTKQLCKLIRGAKALTDIVPLTQEAE
LELAENREILKEPAHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTETVQKIAQECIVIWGKTPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006