Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2251 | 2251-30925 | Portugal | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82A | L24I, F53L, G73GCFV | L10I, T12I, I15V, G17E, K20M, E35D, M36I, K43R, R57K, Q61N, I62IV, L63P, T91TS |
| >2251-30925| codons 1-99 PQITLWQRPIVIIKVGEQLMEALIDTGADDTVLEDINLPGRWRPKMIMGIGGLVKVKQYD NVPIEICGHKAIVTVLVGPTPANIIGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | K219R | Y181C | V108I, K238N | T7TA, K20R, V35VAIT, K43E, E44D, V60I, K101Q, V118I, K122E, I135L, S162Y, K173A, Q174K, I178L, G196E, Q197L, E203K, Q207E, R211A, K223Q, L228H, D237E, V241M, V245Q, E248D, A272P, L283I, T286A, E291D, V292VI, I293V, V314VA, V317A, R356K, G359S, A371T, T377LQ, S379C, K390R, E399D | V276VAIT, E297HQ |
| >2251-30925| codons 1-399 PISPIEAVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEEDGKISKIGPENPYNTPI FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRAKNPDLVI CQYVDDLYVGSDLEIELHRTKIKELREHLWAWGFYTPDRKHQQEPPFHWMGYELHPENWT MQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKTKQLCKLIRGAKALTDIVPLTQEAE LELAENREILKEPAHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTETVQKIAQECIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |