Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2245 | 2245-30722 | Portugal | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L33F | L10I, I13V, K20V, E35D, M36V, N37C, L63P, I64V, A71V, V77I, I93L, C95CF |
| >2245-30722| codons 1-99 PQITLWQRPIVTVKIGGQLVEALLDTGADDTVFEDVCLPGRWKPKIIGGVGGFVKVRQYD QIPVEICGHKVIGTVLIGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219E | K103N | K20R, V35R, K122E, D123N, I135T, E203K, Q207S, R211K, T286A, E297K, V317A, D324E, I326V, A371V, A376ST, T377L |
| >2245-30722| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALREICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELRSHLLKWGFFTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGAYYDPSKELVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEVVQKITLESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |