<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2244 2244-30722 Portugal 2003 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I54V, V82A, L90M K43T, G73T L10V, I15V, K20R, M36I, R41N, K55R, D60E, L63P, H69HR, K70R, A71V, I93L, C95V  
>2244-30722| codons 1-99
PQITLWQRPVVTIKVGGQLREALLDTGADDTILEEINLPGNWTPKIIGGIGGFVRVRQYE
QIPIEICGRRVITTVLVGPTPANIIGRNLMTQLGVTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, T215Y D67G, V75I     P1L, I2V, V35T, V60I, V118I, K122E, D123N, I132L, T165I, D177E, I178L, E204K, Q207E, F214L, L228R, V245K, K249Q, D250E, A272P, T286V, I293V, E297R, I329V, R356K, G359N, A360AT, T369A, A371T, T377L, T386I, A400L  
>2244-30722| codons 1-400
LVSPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPI
FAIKKKGSDKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTLPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPELVI
YQYMDDLYVGSDLEIGQHRTKIEKLREHLLRWGLYTPDKKHQKEPPFRWMGYELHPDKWT
VQPIKLPEQESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGVKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYAKMRNT
HTNDVKQLAETVQKIALESIVIWGKIPKFKLPIQKETWEL

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006