Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2244 | 2244-30722 | Portugal | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | K43T, G73T | L10V, I15V, K20R, M36I, R41N, K55R, D60E, L63P, H69HR, K70R, A71V, I93L, C95V |
| >2244-30722| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTILEEINLPGNWTPKIIGGIGGFVRVRQYE QIPIEICGRRVITTVLVGPTPANIIGRNLMTQLGVTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, T215Y | D67G, V75I | I2V, V35T, V60I, V118I, K122E, D123N, I132L, T165I, D177E, I178L, E204K, Q207E, F214L, L228R, V245K, K249Q, D250E, A272P, T286V, I293V, E297R, I329V, R356K, G359N, A360AT, T369A, A371T, T377L, T386I |
| >2244-30722| codons 2-399 VSPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPIF AIKKKGSDKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPLD ENFRKYTAFTLPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPELVIY QYMDDLYVGSDLEIGQHRTKIEKLREHLLRWGLYTPDKKHQKEPPFRWMGYELHPDKWTV QPIKLPEQESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGVKALTEVVPLTREAEL ELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYAKMRNTH TNDVKQLAETVQKIALESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |