Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2241 | 2241-30722 | Portugal | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, V75M, L210W, T215Y | D67H, K219Q | K101E, Y188YFHL, G190S | V35VM, T39A, E40F, K43E, V60I, V118I, K122E, R172RK, N175H, I178L, V179VI, T200A, K201I, H208Y, L228H, Q242QH, A272P, T286A, V317A, V365I, T386TI, K390R |
| >2241-30722| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAFLEEEGKISKIGPENPYNTPI FAIKKKHSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQHPDLII YQYMDDLLVSSDLEIGQHRAIIEELRQYLWRWGFYTPDQKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDIKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L10FI, L24I, Q58E | I13V, E35D, M36I, N37D, I62V, L63P, A71T, T91S | A22C |
| >2241-30722| codons 1-99 PQITLWQRPIVTVKIGGQLKECLIDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVREYD QVPIEICGHKTIGTVLVGPTPANIIGRNLLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |