<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2241 2241-30722 Portugal 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A L10FI, L24I, Q58E I13V, E35D, M36I, N37D, I62V, L63P, A71T, T91S A22C
>2241-30722| codons 1-99
PQITLWQRPIVTVKIGGQLKECLIDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVREYD
QVPIEICGHKTIGTVLVGPTPANIIGRNLLSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L210W, T215Y D67H, V75M, K219Q K101E, Y188YFHL, G190S   V35VM, T39A, E40F, K43E, V60I, V118I, K122E, R172RK, N175H, I178L, V179VI, T200A, K201I, H208Y, L228H, Q242QH, A272P, T286A, V317A, V365I, T386TI, K390R  
>2241-30722| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAFLEEEGKISKIGPENPYNTPI
FAIKKKHSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQHPDLII
YQYMDDLLVSSDLEIGQHRAIIEELRQYLWRWGFYTPDQKHQKEPPFHWMGYELHPDKWT
VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDIKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006