Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2240 | 2240-30722 | Portugal | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | Y188L | T39K, E40F, K43E, V60I, K102KR, V106I, K122P, I135T, I178L, V179I, V189I, T200TA, H208Y, R211K, K223Q, L228H, V245E, L283I, T286A, I293V, P294T, E297K, K311R, A355E, M357T, K390R |
| >2240-30722| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKFLEEEGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLII YQYMDDLLIGSDLEIGQHRAKIEELRQYLWKWGFYTPDKKHQQEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGAKALTEVVTLTKEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYERTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, L76V, V82C, I84IV, L90M | V11I, Q58QE, G73AT, L89LV | L10V, I13V, I15V, Q18H, K20I, M36I, N37D, D60E, I62V, L63P, A71V, I72L | T80TAS |
| >2240-30722| codons 1-99 PQITLWQRPVITVKVGGHLIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFLKVREYE QVPIEICGHKVLTTVVVGPSPCNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |