<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2240 2240-30722 Portugal 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54L, L76V, V82C, I84IV, L90M V11I, Q58QE, G73AT, L89LV L10V, I13V, I15V, Q18H, K20I, M36I, N37D, D60E, I62V, L63P, A71V, I72L T80TAS
>2240-30722| codons 1-99
PQITLWQRPVITVKVGGHLIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFLKVREYE
QVPIEICGHKVLTTVVVGPSPCNVIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, V75M, L210W, T215Y   Y188L   T39K, E40F, K43E, V60I, K102KR, V106I, K122P, I135T, I178L, V179I, V189I, T200TA, H208Y, R211K, K223Q, L228H, V245E, L283I, T286A, I293V, P294T, E297K, K311R, A355E, M357T, K390R  
>2240-30722| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKFLEEEGKISKIGPENPYNTPI
FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL
DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLII
YQYMDDLLIGSDLEIGQHRAKIEELRQYLWKWGFYTPDKKHQQEPPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGAKALTEVVTLTKEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYERTRGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006