<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2230 2230-30616 Portugal 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, L33F, G73T N37D, K55R, I62V, L63P, I66V, C67F, H69HR, I72K, P79A, I93L, C95V  
>2230-30616| codons 1-99
PQITLWQRPFVTIKIGGQLKEALLDTGADDTVFEEMDLPGRWKPKIIGGIGGFVRVRQYD
QVPIEVFGRKAKTTVLVGATPVNVIGRNLMTQLGVTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70G, V75T, Q151M, M184V A62V K103N, Y181C   K20R, E28A, S68N, A98S, I142T, S162N, R172K, G196E, F214L, L228HR, V245E, A272P, T286A, V292I, E297K, D324E, Y354F, M357T, A360T, A376S, K390R  
>2230-30616| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTAEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FVIKKKDNTGWRKLTDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGTRYQYNVLPMGWKGSPAIFQNSMTKILEPFKKQNPDIVI
CQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFRWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKFARTRGT
HTNDVKQLTEAVQKISTESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006