<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2228 2228-30506 Portugal 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47IV, V82A, L90M   L10I, E34EQ, N37D, L63P, I64IV, C67S, A71V, I93L  
>2228-30506| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTILQEMDLPGRWKPKIVGGIGGFIKVRQYD
QIPVEISGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, M184MV, T215F K219Q K103N, Y188YFHL   T39TA, K102Q, I135V, I142IV, S162CY, R172RK, G196E, Q207E, K277R, T286A, I293V, E297K, D324E, Q334E, M357T, A360T, K366R, A376AGST, K390R, E399D  
>2228-30506| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFKKQNPDIVI
YQYVDDLLVGSDLEIEQHRTKIEELREHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTRGT
HTNDVRQLTEAVQKITTESIVIWGKTPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006