<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2227 2227-30430 Portugal 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L74V, Y115F, M184V, T215F D67H, K219E Y181IS   I5IV, V35T, K43R, I50V, A98S, K122E, D123S, Q174R, R211K, F214L, D218E, L228LH, A272P, K277R, V292I, E297K, G359S, K366R, A371V, A376S, K390R  
>2227-30430| codons 1-399
PISPVETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEREGKISKVGPENPYNTPV
FAIKKKHSTRWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAFFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI
SQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGLFTPEEKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVRQLTEVVQKISTESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, I84V, L90M   L10LI, I13AV, K14R, K20IV, A22AV, E35D, M36I, N37D, R41K, K45V, L63LP, I64IV, I66IV, H69K, A71AT, V82I, L89I, Q92K  
>2227-30430| codons 1-99
PQITLWQRPIVTVRIGGQLVEVLLDTGADDTVLEDIDLPGKWKPVMIGGIGGFVKVRQYD
QIPVEVCGKKTIGTVLVGPTPINVIGRNIMTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006