Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2227 | 2227-30430 | Portugal | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74V, Y115F, M184V, T215F | D67H, K219E | Y181IS | I5IV, V35T, K43R, I50V, A98S, K122E, D123S, Q174R, R211K, F214L, D218E, L228LH, A272P, K277R, V292I, E297K, G359S, K366R, A371V, A376S, K390R |
| >2227-30430| codons 1-399 PISPVETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEREGKISKVGPENPYNTPV FAIKKKHSTRWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAFFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI SQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGLFTPEEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVRQLTEVVQKISTESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10LI, I13AV, K14R, K20IV, A22AV, E35D, M36I, N37D, R41K, K45V, L63LP, I64IV, I66IV, H69K, A71AT, V82I, L89I, Q92K |
| >2227-30430| codons 1-99 PQITLWQRPIVTVRIGGQLVEVLLDTGADDTVLEDIDLPGKWKPVMIGGIGGFVKVRQYD QIPVEVCGKKTIGTVLVGPTPINVIGRNIMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |