Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2226 | 2226-30423 | Portugal | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K101E, Y181C, G190A | K20R, E28K, K32E, T39A, E44D, V118I, K122E, I135T, S162T, R172K, E203D, Q207K, R211A, K223Q, V245K, S251I, T286P, I293V, E297K, I329L, Q334D, P345E, R356K, A376S, T386I, K390R |
| >2226-30423| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQTSMTKILEPFKKQNPDIVI CQYMDDLYVASDLEIGQHRTKIDELRKHLWAWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIKLPEKDIWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGPKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGDGQWTYQIYQEEFKNLKTGKYAKMRGA HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76LV, V82A, L90M | L10I, T12P, K14R, K20M, E34Q, E35D, M36I, N37S, R41K, I62V, L63T, I64V, A71V, T74S, I93L |
| >2226-30423| codons 1-99 PQITLWQRPIVPIRIGGQLMEALLDTGADDTVLQDISLPGKWKPKLIGGIGGFVKVRQYD QVTVEICGHKVIGSVVVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |