<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2226 2226-30423 Portugal 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, L76LV, V82A, L90M   L10I, T12P, K14R, K20M, E34Q, E35D, M36I, N37S, R41K, I62V, L63T, I64V, A71V, T74S, I93L  
>2226-30423| codons 1-99
PQITLWQRPIVPIRIGGQLMEALLDTGADDTVLQDISLPGKWKPKLIGGIGGFVKVRQYD
QVTVEICGHKVIGSVVVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y   K101E, Y181C, G190A   K20R, E28K, K32E, T39A, E44D, V118I, K122E, I135T, S162T, R172K, E203D, Q207K, R211A, K223Q, V245K, S251I, T286P, I293V, E297K, I329L, Q334D, P345E, R356K, A376S, T386I, K390R  
>2226-30423| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALVEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQTSMTKILEPFKKQNPDIVI
CQYMDDLYVASDLEIGQHRTKIDELRKHLWAWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIKLPEKDIWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGPKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGDGQWTYQIYQEEFKNLKTGKYAKMRGA
HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006