Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2225 | 2225-30423 | Portugal | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219E | K103N, Y181C | E28EK, V35T, K43R, K49KR, V60I, T69N, A98S, K122E, D123S, I135T, K173T, Q174K, D177E, T200A, I202IV, Q207K, R211S, H221Y, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297V, D320E, D324E, I329V, Q334P, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, Q394R |
| >2225-30423| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALTEICTEMEREGKISRIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI CQYVDDLYVGSDLEIGQHRAKVEELRKHLLSWGFTTPDEKYQKEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTVEAE LELAENREILKEPVHGVYYEPSKELIAEVQKQGPDQWTYQIYQEPYKNLKTGKYAKRGSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIRKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82A | F53L | I13V, K14R, K20I, E35D, M36I, N37D, R41K, L63P, H69K, K70R, A71IV, L89I, T91TS |
| >2225-30423| codons 1-99 PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEDIDLPGKWKPKIVGGIGGLVKVRQYD QIPIEICGKRVIGTVLVGPTPANIIGRNILSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |