<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2225 2225-30423 Portugal 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, V82A F53L I13V, K14R, K20I, E35D, M36I, N37D, R41K, L63P, H69K, K70R, A71IV, L89I, T91TS  
>2225-30423| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEDIDLPGKWKPKIVGGIGGLVKVRQYD
QIPIEICGKRVIGTVLVGPTPANIIGRNILSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V K219E K103N, Y181C   E28EK, V35T, K43R, K49KR, V60I, T69N, A98S, K122E, D123S, I135T, K173T, Q174K, D177E, T200A, I202IV, Q207K, R211S, H221Y, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297V, D320E, D324E, I329V, Q334P, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, Q394R  
>2225-30423| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALTEICTEMEREGKISRIGPENPYNTPI
FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI
CQYVDDLYVGSDLEIGQHRAKVEELRKHLLSWGFTTPDEKYQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTVEAE
LELAENREILKEPVHGVYYEPSKELIAEVQKQGPDQWTYQIYQEPYKNLKTGKYAKRGSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIRKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006