Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2212 | 2212-30624 | Portugal | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, K70R | D67G, T215I, K219Q | K103N | K20R, V35T, V60I, A98S, K122E, D123S, I135L, S162A, K173R, Q174K, N175Y, D177E, T200A, Q207E, H208Y, R211K, L228H, V245Q, E248D, D250E, A272P, L283LI, T286A, A288T, E291D, V292I, I293V, E297A, D324E, I329V, Q334L, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, T386I, K390R, Q394R, E399D |
| >2212-30624| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKGSDRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRRKYPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREYLLKWGFITPDQKHQKEPPFHWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGAKTLTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKELIAEVQKQGLDQWTYQIYQEPYKNLKTGKYAKRGSA HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIRKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82VFI, L90M | L23LI, F53FL, L89MV | L10LI, I13AV, K14R, K20I, E35G, M36I, R41K, D60E, L63P, H69KR, A71V, T74S, I93L |
| >2212-30624| codons 1-99 PQITLWQRPIVTVRIGGQLIEAILDTGADDTVLEGINLPGKWKPKMIGGIGGLVKVRQYE QIPIEICGRKVIGSVLVGPTPINIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |