<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2211 2211-30526 Portugal 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54M, N88S, L90M   L10I, K14R, I15V, L19T, K20T, E34EQ, E35DN, M36I, N37S, L63LP, A71I, G73GD, T74S, V77I, I85V, Q92K, I93L  
>2211-30526| codons 1-99
PQITLWQRPIVTIRVGGQTTEALLDTGADDTVLQNISLPGRWKPKMIGGIGGFMKVRQYD
QIPIEICGHKIIDSVLIGPTPVNIVGRSLMTKLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69TADN, L74V, L210W, T215Y A62AV, K219R     V35M, T39A, K43E, E44ED, L109I, V118I, D123E, I135T, T200TI, H208Y, R211K, D218E, L228H, I293V, E297R, Q334L, R356K, A360V, T377TI, K390R  
>2211-30526| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEDGKISKIGPENPYNTPV
FVIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVIDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRIKIEELRQYLWKWGFYTPERKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRGV
HTNDVKQLTEAVQKIAIESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006