Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2211 | 2211-30526 | Portugal | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54M, N88S, L90M | L10I, K14R, I15V, L19T, K20T, E34EQ, E35DN, M36I, N37S, L63LP, A71I, G73GD, T74S, V77I, I85V, Q92K, I93L |
| >2211-30526| codons 1-99 PQITLWQRPIVTIRVGGQTTEALLDTGADDTVLQNISLPGRWKPKMIGGIGGFMKVRQYD QIPIEICGHKIIDSVLIGPTPVNIVGRSLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69TADN, L74V, L210W, T215Y | A62AV, K219R | V35M, T39A, K43E, E44ED, L109I, V118I, D123E, I135T, T200TI, H208Y, R211K, D218E, L228H, I293V, E297R, Q334L, R356K, A360V, T377TI, K390R |
| >2211-30526| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEDGKISKIGPENPYNTPV FVIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVIDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRIKIEELRQYLWKWGFYTPERKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRGV HTNDVKQLTEAVQKIAIESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |