<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2204 2204-30401 Portugal 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, M184MV, L210W, T215Y K219R K101E, Y181C, G190A V108I K20R, V35I, T39TA, K43DE, E44D, R83K, V118I, K122E, D123DN, D177E, T200AE, E203K, Q207D, H208Y, R211K, H221Y, L228H, T286A, I293V, T296S, E297K, G359S, V365I, A371V, I375V, A376S, T377Q  
>2204-30401| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEEDGKISKIGPENPYNTPV
FAIKKKNSDKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
CQYVDDLYVASDLEIGQHREKIKELRDYLWKWGFYTPDRKYQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLSKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDIKQLTEVVQKVSQESIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, I84V, L90M L10F K20I, E34Q, E35E_G, M36I, G51A, K55R, R57RK, I62V, L63P, I66F, C67Y, A71L, I72V, Q92K  
>2204-30401| codons 1-99
PQITLWQRPFVTIKIGGQLIEALLDTGADDTVLQEINLPGRWKPKIIGGIAGFVRVKQYD
QVPIEFYGHKLVGTVVVGPTPVNVIGRNLMTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006