Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2204 | 2204-30401 | Portugal | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V, L90M | L10F | K20I, E34Q, E35E_G, M36I, G51A, K55R, R57RK, I62V, L63P, I66F, C67Y, A71L, I72V, Q92K |
| >2204-30401| codons 1-99 PQITLWQRPFVTIKIGGQLIEALLDTGADDTVLQEINLPGRWKPKIIGGIAGFVRVKQYD QVPIEFYGHKLVGTVVVGPTPVNVIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184MV, L210W, T215Y | K219R | K101E, Y181C, G190A | V108I | K20R, V35I, T39TA, K43DE, E44D, R83K, V118I, K122E, D123DN, D177E, T200AE, E203K, Q207D, H208Y, R211K, H221Y, L228H, T286A, I293V, T296S, E297K, G359S, V365I, A371V, I375V, A376S, T377Q |
| >2204-30401| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEEDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVASDLEIGQHREKIKELRDYLWKWGFYTPDRKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLSKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDIKQLTEVVQKVSQESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |