Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2203 | 2203-30401 | Portugal | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47A | Q58QE | L10V, L63P, A71T, I72V, V77I, I85V, Q92K |
| >2203-30401| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTILEEMNLPGRWKPKIAGGIGGFIKVREYD QIPIEICGHKTVGTVLIGPTPVNIVGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | N348I | L100I, K103N | P4T, D123E, I178IM, T200A, R211K, K277R, Q278E, I293V, P294T, E297R, Q334L, R356K, A360V, T377R, V381I, K390R, Q394T, E399D |
| >2203-30401| codons 1-400 PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLLRGTKALTEVVTLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKILKTGKYAKMRGV HTNDVKQLTEAVQKIARESIIIWGKTPKFRLPITKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |