Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2202 | 2202-30331 | Portugal | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V | L63P, C67S, V77I, V82I |
| >2202-30331| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGVGGFIKVRQYD QIPIEISGHKAIGTVLIGPTPINIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K49KR, K122KE, D123E, I142T, S162C, R211K, V245E, D250E, S251N, A272P, K277R, I293V, E297A, D324DE, F346C, R358RK, T377M, K390R, Q394T, E399D, A400S |
| >2202-30331| codons 2-400 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPVF AIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD EEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVIY QYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWTV QPIELPEKENWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAEL ELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPCKNLKTGKYARMKGAH TNDVKQLTEAVQKIAMESIVIWGKTPKFRLPITKETWDS |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |