Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2201 | 2201-30331 | Portugal | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_VG, L210W, T215Y | D67G, K70T | G190A | K101H | V35I, E44D, A98S, K122E, I135T, G196E, D250E, A272P, K277R, I293V, S322T, Q334N, R358K, A376T, T386M, K390R | S68A, L92M |
| >2201-30331| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKDGKISKIGPENPYNTPV FAIKKKGASTWRKLVDFRELNKRTQDFWEVQMGIPHPSGLHKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLTEAVQKITTESIVIWGKMPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | L33F, G73A | L10I, V11L, I13V, N37H, R41K, K45R, L63P, A71V, V77I, I93L |
| >2201-30331| codons 1-99 PQITLWQRPILTVKIGGQLKEALLDTGADDTVFEEMHLPGKWKPRMIGGIGGFLKVRQYD QIPIEICGHKVIATVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |