Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2026 | 2026-30429 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| Q58E | K14KR, E35D, M36I, D60E, Q61E, I62V, L63E, I64V, E65D, K70R, I72IV |
| >2026-30429| codons 1-99 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVREYE EVEVDICGHRAVGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K122E, I202IV, R211K, A272P, T286A, A288AS, I293IV, E297K, L310LI, E312D, I326V, Q334E, M357T, K366R, T369TA, E370ED, A371AV, K374KR, I375IV, A376T, T377L |
| >2026-30429| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKVEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKSLTEVVPLTKEAE LELAENREIIKDPVHGVYYDPSKDLVAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVRQLADVVQRVTLESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |